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Article Dans Une Revue PLoS Neglected Tropical Diseases Année : 2023

Candida haemulonii complex, an emerging threat from tropical regions?

Ugo Françoise
Marie Desnos-Ollivier
  • Fonction : Auteur
Karine Sitbon
  • Fonction : Auteur
Ruddy Valentino
  • Fonction : Auteur
Sandrine Peugny
  • Fonction : Auteur
Taieb Chouaki
  • Fonction : Auteur
Edith Mazars
  • Fonction : Auteur
André Paugam
  • Fonction : Auteur
Muriel Nicolas
  • Fonction : Auteur
Nicole Desbois-Nogard
  • Fonction : Auteur
Olivier Lortholary

Résumé

Background Candida haemulonii complex-related species are pathogenic yeasts closely related to Candida auris with intrinsic antifungal resistance, but few epidemiological data are available. Methodology/Principal findings We analyzed clinical and demographic characteristics of patients with fungemia due to C . haemulonii complex and related species ( C . pseudohaemulonii , C . vulturna ) reported in France during 2002–2021, and compared them to data of C . parapsilosis fungemia, as they all can be commensal of the skin. We also conducted a study on adult inpatients and outpatients colonized by C . haemulonii complex, managed at the University Hospital of Martinique during 2014–2020. Finally, we performed a literature review of fungemia due to C . haemulonii complex and related species reported in Medline (1962–2022). In total, we identified 28 fungemia due to C . haemulonii complex in France. These episodes were frequently associated with bacterial infection (38%) and high mortality rate (44%), and differed from C . parapsilosis fungemia by their tropical origin, mainly from Caribbean and Latin America. All isolates showed decreased in vitro susceptibility to amphotericin B and fluconazole. In Martinique, we found that skin colonization was frequent in the community population, while colonization was strongly associated with the presence of foreign devices in ICU patients. The literature review identified 274 fungemia episodes, of which 56 were individually described. As in our national series, published cases originated mainly from tropical regions and exhibited high crude mortality. Conclusions/Significance Multidrug-resistant C . haemulonii complex-related species are responsible for fungemia and colonization in community and hospital settings, especially in tropical regions, warranting closer epidemiological surveillance to prevent a potential C . auris- like threat.
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hal-04211257 , version 1 (23-01-2024)

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Ugo Françoise, Marie Desnos-Ollivier, Yohann Le Govic, Karine Sitbon, Ruddy Valentino, et al.. Candida haemulonii complex, an emerging threat from tropical regions?. PLoS Neglected Tropical Diseases, 2023, 17 (7), pp.e0011453. ⟨10.1371/journal.pntd.0011453⟩. ⟨hal-04211257⟩
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