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Chapitre D'ouvrage Année : 2013

Neurofilaments: Properties, Functions, and Regulation - Springer

Rodolphe Perrot
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Joël Eyer
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Rolf Dermietzel
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Neuronal intermediate filaments are the most prominent cytoskeleton component of adult neurons in both central and peripheral nervous system. They include neurofilament triplet proteins, peripherin, α-internexin, nestin, and synemin. Although it was initially thought that neuronal intermediate filaments serve a primarily structural function, it has since been demonstrated that they constitute a dynamic network involved in neuronal differentiation, axon outgrowth, and regeneration. Finally, they emerged as a primary cause of some neurodegenerative diseases. Here, we focus on the properties, function, and regulation of neuronal intermediate filaments as well as their relationship to different neurodegenerative diseases.

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Dates et versions

hal-03403289 , version 1 (26-10-2021)


  • HAL Id : hal-03403289 , version 1
  • OKINA : ua9045


Rodolphe Perrot, Joël Eyer, Rolf Dermietzel. Neurofilaments: Properties, Functions, and Regulation - Springer. The Cytoskeleton, 79, Humana Press, pp.171 - 236, 2013, 978-1-62703-265-0. ⟨hal-03403289⟩


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