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Article Dans Une Revue Thyroid Année : 2008

Thyroxine Therapy in Euthyroid Patients Does Not Affect Body Composition or Muscular Function

Résumé

OBJECTIVE:The main objective of the study was to evaluate the effects of small increments in thyroxine (T4) levels following levothyroxine (L-T4) administration on the body composition of women patients. The secondary objective was to assess the effect of the therapy on energy expenditure and muscular function. METHODS: The prospective, randomized study consisted of a 12-month follow-up of 37 women with thyroid nodules. The patients were divided into two groups for comparison, one treated with L-T4 (20 women) and the other untreated (17 women). L-T4 dose was individually adjusted to obtain a serum thyroid-stimulating hormone in the lower portion of the normal range. Multiple tests, including bioelectrical impedance analysis, dual-energy X-ray absorptiometry, air displacement plethysmography, measurement of waist circumference, and skinfold anthropometry, were used to investigate the muscular, fat, and water compartments; energy expenditure and muscular function were assessed by cycle ergometry. RESULTS: There were no significant differences in body composition, heart rate, energy metabolism, or muscular function between the group of women treated with L-T4 and the untreated group. CONCLUSION: The controlled increase of circulating T4 does not appear to modify the body composition or muscular function in women patients.

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Dates et versions

hal-03275628 , version 1 (01-07-2021)

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Séverine Dubois, Pierre Abraham, Vincent Rohmer, Patrice Rodien, Maurice Audran, et al.. Thyroxine Therapy in Euthyroid Patients Does Not Affect Body Composition or Muscular Function. Thyroid, 2008, 18 (1), pp.13 - 19. ⟨10.1089/thy.2007.0037⟩. ⟨hal-03275628⟩

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