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Article Dans Une Revue International Journal of Pharmaceutics Année : 2009

The gastrointestinal stability of lipid nanocapsules

Résumé

The in vitro gastrointestinal stability of lipid nanocapsules (LNCs) was studied in different media. The size of LNCs was determined in simulated gastric and intestinal media. In updated fasted state simulated intestinal fluid (FaSSIF-V2) and updated fed state simulated intestinal fluid (FeSSIF-V2) media, the encapsulation ratio of paclitaxel-loaded LNCs was also measured. The size of LNCs was not modified after 3h in simulated gastric fluid and simulated intestinal fluid described by the United States Pharmacopeia, in FaSSIF, FaSSIF-V2, and in FeSSIF. Moreover, in the presence of pancreatin in FeSSIF-V2, a decreased above 30% of the loading of paclitaxel was observed. This was attributed to the presence of lipase in pancreatin that could interact with Lipoid (a mixture of phosphatidylcholine and phosphatidylethanolamine), present on the shell of LNC. As a conclusion, LNCs were stable on gastric medium and fasted state intestinal medium.

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Dates et versions

hal-03171870 , version 1 (17-03-2021)

Identifiants

  • HAL Id : hal-03171870 , version 1
  • OKINA : ua3736

Citer

Emilie Roger, Frédéric Lagarce, Jean-Pierre Benoît. The gastrointestinal stability of lipid nanocapsules. International Journal of Pharmaceutics, 2009, 379 (2), pp.260-5. ⟨hal-03171870⟩

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