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Article Dans Une Revue Drug Metabolism Reviews Année : 2009

Therapeutic management of allergic diseases

Jean-Baptiste Watelet
  • Fonction : Auteur
Michel Gillard
  • Fonction : Auteur
Margherita Benedetti
  • Fonction : Auteur


Allergic diseases are characterized by the activation of inflammatory cells and by a massive release of mediators. The aim of this chapter was to describe succinctly the modes of action, indications, and side effects of the major antiallergic and antiasthmatic drugs. When considering the ideal pharmacokinetic characteristics of a drug, a poorly metabolized drug may confer a lower variability in plasma concentrations and metabolism-based drug interactions, although poorly metabolized drugs may be prone to transporter-based disposition and interactions. The ideal pharmacological properties of a drug include high binding affinity, high selectivity, and appropriate association and dissociation rates. Finally, from a patient perspective, the frequency and route of administration are important considerations for ease of use.

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Dates et versions

hal-03134755 , version 1 (08-02-2021)



Jean-Baptiste Watelet, Michel Gillard, Margherita Benedetti, Bénédicte Lelièvre, Bertrand Diquet. Therapeutic management of allergic diseases. Drug Metabolism Reviews, 2009, 41 (3), pp.301 - 343. ⟨10.1080/10837450902891204⟩. ⟨hal-03134755⟩


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