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Article Dans Une Revue Journal of Bone and Mineral Research Année : 2020

Enteroendocrine K Cells Exert Complementary Effects to Control Bone Quality and Mass in Mice

Sagar Vyavahare
  • Fonction : Auteur
Liv Vv V V Blom
  • Fonction : Auteur
Kristian K Pedersen
  • Fonction : Auteur
Johanne A Windeløv
  • Fonction : Auteur
Geke A Boer
  • Fonction : Auteur
Norio Harada
  • Fonction : Auteur
Sheng Zhang
  • Fonction : Auteur
Satoko Shimazu‐kuwahara
  • Fonction : Auteur
Burton Wice
  • Fonction : Auteur
Nobuya Inagaki
  • Fonction : Auteur
Peter R Flatt
  • Fonction : Auteur
Bolette Hartmann
  • Fonction : Auteur
Jens J Holst
  • Fonction : Auteur
Mette M Rosenkilde
  • Fonction : Auteur
Nigel Irwin
  • Fonction : Auteur


The involvement of a gut-bone axis in controlling bone physiology has been long suspected, although the exact mechanisms are unclear. We explored whether glucose-dependent insulinotropic polypeptide (GIP)-producing enteroendocrine K-cells were involved in this process. The bone phenotype of transgenic mouse models lacking GIP secretion (GIP-GFP-KI) or enteroendocrine K-cells (GIP-DT) was investigated. Mice deficient in GIP secretion exhibited lower bone strength, trabecular bone mass, trabecula number and cortical thickness, notably due to higher bone resorption. Alterations of microstructure, modifications of bone compositional parameters, represented by lower collagen cross-linking were also apparent. None of these alterations were observed in GIP-DT mice lacking enteroendocrine K-cells, suggesting that other K-cell secretory product acts to counteract GIP action. To assess this, stable analogues of the known K-cell peptide hormones, xenin and GIP, were administered to mature NIH Swiss male mice. Both were capable of modulating bone strength mostly by altering bone microstructure, bone gene expression and bone compositional parameters. However, the two molecules exhibited opposite actions on bone physiology, with evidence that xenin effects are mediated indirectly, possibly via neural networks. Our data highlight a previously unknown interaction between GIP and xenin, which both moderate gut-bone connectivity.
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Dates et versions

hal-02946043 , version 1 (22-09-2020)



Benoît Gobron, Béatrice Bouvard, Sagar Vyavahare, Liv Vv V V Blom, Kristian K Pedersen, et al.. Enteroendocrine K Cells Exert Complementary Effects to Control Bone Quality and Mass in Mice. Journal of Bone and Mineral Research, 2020, 35 (7), pp.1363-1374. ⟨10.1002/jbmr.4004⟩. ⟨hal-02946043⟩


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