Contryphan-Vn: a modulator of Ca2+-dependent K+ channels. - Université d'Angers Accéder directement au contenu
Article Dans Une Revue Biochemical and Biophysical Research Communications Année : 2003

Contryphan-Vn: a modulator of Ca2+-dependent K+ channels.

Résumé

Contryphan-Vn is a D-tryptophan-containing disulfide-constrained nonapeptide isolated from the venom of Conus ventricosus, the single Mediterranean cone snail species. The structure of the synthetic Contryphan-Vn has been determined by NMR spectroscopy. Unique among Contryphans, Contryphan-Vn displays the peculiar presence of a Lys-Trp dyad, reminiscent of that observed in several voltage-gated K(+) channel blockers. Electrophysiological experiments carried out on dorsal unpaired median neurons isolated from the cockroach (Periplaneta americana) nerve cord on rat fetal chromaffin cells indicate that Contryphan-Vn affects both voltage-gated and Ca(2+)-dependent K(+) channel activities, with composite and diversified effects in invertebrate and vertebrate systems. Voltage-gated and Ca(2+)-dependent K(+) channels represent the first functional target identified for a conopeptide of the Contryphan family. Furthermore, Contryphan-Vn is the first conopeptide known to modulate the activity of Ca(2+)-dependent K(+) channels.

Dates et versions

hal-00188894 , version 1 (19-11-2007)

Identifiants

Citer

Gabriella Raybaudi Massilia, Tommaso Eliseo, Francoise Grolleau, Bruno Lapied, Julien Barbier, et al.. Contryphan-Vn: a modulator of Ca2+-dependent K+ channels.. Biochemical and Biophysical Research Communications, 2003, 303 (1), pp.238-46. ⟨10.1016/S0006-291X(03)00331-0⟩. ⟨hal-00188894⟩
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