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Article Dans Une Revue Cell Adhesion and Migration Année : 2016

Spitting out the demons: Extracellular vesicles in glioblastoma

Résumé

Discovered decades ago, extracellular vesicles (EVs) emerge as dedicated organelles, able to deliver protected, specific cellular cues throughout the organism. While virtually every cell can release EVs, cancer cells co-opted this feature and efficiently unleashed them both in the tumor microenvironment and towards healthy tissues. This might contribute to tumor aggressiveness and spreading. Cancer-derived EVs that contain DNA, mRNA, miRNA, and packed and transmembrane proteins can operate locally or at distance. This review will focus on the high-grade brain tumor (i.e. glioblastoma)-derived EVs, discussing recent reports on i) their phenotype and content, ii) their putative functions, and iii) their clinical potential for improving diagnosis and therapeutics.

Domaines

Cancer
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Dates et versions

inserm-01382405 , version 1 (17-10-2016)

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Gwennan André-Grégoire, Julie Gavard. Spitting out the demons: Extracellular vesicles in glioblastoma. Cell Adhesion and Migration, 2016, 11 (2), pp.164-172. ⟨10.1080/19336918.2016.1247145⟩. ⟨inserm-01382405⟩
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