Is ABCC6 a genuine mitochondrial protein? - Université d'Angers Accéder directement au contenu
Article Dans Une Revue BMC Research Notes Année : 2013

Is ABCC6 a genuine mitochondrial protein?

Résumé

BACKGROUND: A recent article in Circulation Research suggests that the protein ABCC6, which when defective is responsible for pseudoxanthoma elasticum, an inherited condition with skin, eye and cardiovascular manifestations, is associated with dysfunction in mitochondria -- Martin et al.: ABCC6 Localizes to the Mitochondria-Associated Membrane. Circ Res 2012, 111:516--520. We present complementary information based on a bioinformatics analysis, which was not performed in the article cited, to examine the suggestion that ABCC6 is localized to mitochondria. RESULTS: All the computational strategies and integrative approaches that constitute references in the field indicate that ABCC6 is localized outside of mitochondria. CONCLUSION: Our computational and integrative results, including both experimental and predictive data, show that there is no support in favor of the localization of ABCC6 in mitochondria.
Fichier principal
Vignette du fichier
1756-0500-6-427.pdf (129.84 Ko) Télécharger le fichier
1756-0500-6-427.xml (24.28 Ko) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte
Format : Autre
Loading...

Dates et versions

inserm-00877607 , version 1 (29-10-2013)

Identifiants

Citer

Marc Ferré, Pascal Reynier, Arnaud Chevrollier, Delphine Prunier-Mirebeau, Georges Lefthériotis, et al.. Is ABCC6 a genuine mitochondrial protein?. BMC Research Notes, 2013, 6 (1), pp.427. ⟨10.1186/1756-0500-6-427⟩. ⟨inserm-00877607⟩
150 Consultations
104 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More