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Article Dans Une Revue Nanomedicine Année : 2024

Elimination study of intact lipid nanocapsules after intravenous rat administration

Résumé

Aim: The present study investigated renal elimination after intravenous administration of four different formulations of lipid nanocapsules (LNCs) containing dyes adapted to Förster resonance energy transfer (FRET-LNCs). Materials & methods: FRET-LNCs of 85 or 50 nm with or without a pegylated surface were injected and collected in the blood or urine of rats at different time points. Quantitative analysis was performed to measure intact FRET-LNCs. Results & conclusion: No intact LNCs were found in urine (0 particles/ml) for all formulations. The 50-nm pegylated LNCs were eliminated faster from the blood, whereas 85-nm pegylated LNCS were eliminated slower than nonpegylated LNCs. Elimination of FRET-LNCs was mainly due to liver tissue interaction and not renal elimination.
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Dates et versions

hal-04569661 , version 1 (04-06-2024)

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Vincent Lebreton, Samuel Legeay, Clara Rapenne, Patrick Saulnier, Frédéric Lagarce. Elimination study of intact lipid nanocapsules after intravenous rat administration. Nanomedicine, 2024, Online ahead of print. ⟨10.2217/nnm-2024-0003⟩. ⟨hal-04569661⟩
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