Adlercreutzia equolifaciens Is an Anti-Inflammatory Commensal Bacterium with Decreased Abundance in Gut Microbiota of Patients with Metabolic Liver Disease - Université d'Angers Accéder directement au contenu
Article Dans Une Revue International Journal of Molecular Sciences Année : 2023

Adlercreutzia equolifaciens Is an Anti-Inflammatory Commensal Bacterium with Decreased Abundance in Gut Microbiota of Patients with Metabolic Liver Disease

Florian Plaza Oñate
Célia Chamignon
  • Fonction : Auteur
Sebastian Burz
Magali Monnoye
  • Fonction : Auteur
  • PersonId : 1206242
Catherine Philippe
  • Fonction : Auteur
Maxime Bredel
  • Fonction : Auteur
Laurent Chêne
  • Fonction : Auteur
William Farin
  • Fonction : Auteur
Jean-Michel Paillarse
  • Fonction : Auteur
Vlad Ratziu
  • Fonction : Auteur
Pierre-Yves Mousset
  • Fonction : Auteur

Résumé

Non-alcoholic fatty liver disease (NAFLD) affects about 20–40% of the adult population in high-income countries and is now a leading indication for liver transplantation and can lead to hepatocellular carcinoma. The link between gut microbiota dysbiosis and NAFLD is now clearly established. Through analyses of the gut microbiota with shotgun metagenomics, we observe that compared to healthy controls, Adlercreutzia equolifaciens is depleted in patients with liver diseases such as NAFLD. Its abundance also decreases as the disease progresses and eventually disappears in the last stages indicating a strong association with disease severity. Moreover, we show that A. equolifaciens possesses anti-inflammatory properties, both in vitro and in vivo in a humanized mouse model of NAFLD. Therefore, our results demonstrate a link between NAFLD and the severity of liver disease and the presence of A. equolifaciens and its anti-inflammatory actions. Counterbalancing dysbiosis with this bacterium may be a promising live biotherapeutic strategy for liver diseases.
Fichier principal
Vignette du fichier
ijms-24-12232-v2.pdf (3.45 Mo) Télécharger le fichier
Origine : Publication financée par une institution

Dates et versions

hal-04214482 , version 1 (13-02-2024)

Licence

Paternité

Identifiants

Citer

Florian Plaza Oñate, Célia Chamignon, Sebastian Burz, Nicolas Lapaque, Magali Monnoye, et al.. Adlercreutzia equolifaciens Is an Anti-Inflammatory Commensal Bacterium with Decreased Abundance in Gut Microbiota of Patients with Metabolic Liver Disease. International Journal of Molecular Sciences, 2023, 24 (15), pp.12232. ⟨10.3390/ijms241512232⟩. ⟨hal-04214482⟩
63 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More