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Article Dans Une Revue F1000Research Année : 2022

An updated version of the Madagascar periwinkle genome

Emily Amor Stander
Hans Jansen
A. Oudin
Arnaud Lanoue
Ron Dirks

Résumé

The Madagascar periwinkle, Catharanthus roseus, belongs to the Apocynaceae family. This medicinal plant, endemic to Madagascar, produces many important drugs including the monoterpene indole alkaloids (MIA) vincristine and vinblastine used to treat cancer worldwide. Here, we provide a new version of the C. roseus genome sequence obtained through the combination of Oxford Nanopore Technologies long-reads and Illumina short-reads. This more contiguous assembly consists of 173 scaffolds with a total length of 581.128 Mb and an N50 of 12.241 Mb. Using publicly available RNAseq data, 21,061 protein coding genes were predicted and functionally annotated. A total of 42.87% of the genome was annotated as transposable elements, most of them being long-terminal repeats. Together with the increasing access to MIA-producing plant genomes, this updated version should ease evolutionary studies leading to a better understanding of MIA biosynthetic pathway evolution

Dates et versions

hal-03994779 , version 1 (17-02-2023)

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Clément Cuello, Emily Amor Stander, Hans Jansen, Thomas Duge de Bernonville, A. Oudin, et al.. An updated version of the Madagascar periwinkle genome. F1000Research, 2022, ⟨10.12688/f1000research⟩. ⟨hal-03994779⟩
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