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Article Dans Une Revue International Journal of Molecular Sciences Année : 2021

Sex Bias in Differentiated Thyroid Cancer


Differentiated thyroid cancers are more frequent in women than in men. These different frequencies may depend on differences in patient’s behavior and in thyroid investigations. However, an impact on sexual hormones is likely, although this has been insufficiently elucidated. Estrogens may increase the production of mutagenic molecules in the thyroid cell and favor the proliferation and invasion of tumoral cells by regulating both the thyrocyte enzymatic machinery and the inflammatory process associated with tumor growth. On the other hand, the worse prognosis of thyroid cancer associated with the male gender is poorly explained.

Dates et versions

hal-03557151 , version 1 (04-02-2022)



Valentine Suteau, Mathilde Munier, Claire Briet, Patrice Rodien. Sex Bias in Differentiated Thyroid Cancer. International Journal of Molecular Sciences, 2021, 22 (23), pp.12992. ⟨10.3390/ijms222312992⟩. ⟨hal-03557151⟩
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