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Article Dans Une Revue Autoimmunity reviews Année : 2010

Anti-Ku antibodies: Clinical, genetic and diagnostic insights

Daniel Henrion
Alain Beucher
  • Fonction : Auteur
A. Ghaali
  • Fonction : Auteur
H. Levesque
  • Fonction : Auteur

Résumé

Anti-Ku antibodies are reported in various connective tissue diseases and the Ku complex can be responsible for a very strong autoimmune answer in autoimmune disease. Nowadays, anti-Ku antibodies are detected by ELISA, counterimmunoelectrophoresis (CIE), immunoblot (IB) and new highly performant techniques. Although the prevalence of anti-Ku antibodies is not homogenous, depending on several features such as disease type, genetic and geographical clustering, and also method of detection, they could be found in 55% overlap PM/systemic sclerosis patients. Moreover, anti-Ku antibodies are not associated with a particular clinical outcome, and especially with cancer related to myositis.

Dates et versions

hal-03408451 , version 1 (29-10-2021)

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Citer

Cristina Belizna, Daniel Henrion, Alain Beucher, Christian Lavigne, A. Ghaali, et al.. Anti-Ku antibodies: Clinical, genetic and diagnostic insights. Autoimmunity reviews, 2010, 9 (10), pp.691 - 4. ⟨10.1016/j.autrev.2010.05.020⟩. ⟨hal-03408451⟩

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