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Article Dans Une Revue Perfusion Année : 2011

Increased cerebral blood flow velocities assessed by transcranial Doppler examination is associated with complement activation after cardiopulmonary bypass

Frédéric Pinaud
  • Fonction : Auteur
Jean-Jacques Corbeau
  • Fonction : Auteur
D. Jolivot
  • Fonction : Auteur
Aram ter Minassian
Daniel Henrion
Jean-Louis de Brux
  • Fonction : Auteur
  • PersonId : 1114851

Résumé

The role of complement activation on the cerebral vasculature after cardiopulmonary bypass (CPB) is unclear. The goal of the study was to assess whether heparin-coated CPB reduces complement activation, and influences cerebral blood flow velocities (CBFV). Twenty-four patients undergoing coronary surgery were randomly allocated to non-coated (NC-group) or heparin-coated (HC-group) CPB. Complement activation was assessed by measuring sC5b-9. Transcranial Doppler (TCD) was performed on middle cerebral arteries before and after CPB. Systolic (SV), diastolic (DV) and mean (MV) CBFV were measured. Significant increase of sC5b-9 (p=0.003) was observed in the NC-group and CBFV increased after CPB (SV by 27%, p=0.05; DV by 40%, p=0.06; MV by 33%, p=0.04) whereas no changes were detected in the HC-group. TCD values were higher in the NC-group than in the HC-group (SV, p=0.04; DV, p=0.03; MV, p=0.03) although cardiac index, systemic vascular resistance, haematocrit and pCO2 were similar. Postoperative SV, DV and MV were significantly correlated with sC5b-9 (r=0.583, p=0.009; r=0.581, p=0.009; r=0.598, p=0.007, respectively). Increased CBFV after CPB are correlated to the level of complement activation and may be controlled by heparin-coated circuits.

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Dates et versions

hal-03405225 , version 1 (27-10-2021)

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Christophe Baufreton, Frédéric Pinaud, Jean-Jacques Corbeau, Alain Chevailler, D. Jolivot, et al.. Increased cerebral blood flow velocities assessed by transcranial Doppler examination is associated with complement activation after cardiopulmonary bypass. Perfusion, 2011, 26 (2), pp.91 - 98. ⟨10.1177/0267659110392439⟩. ⟨hal-03405225⟩
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