%0 Journal Article %T Early compaction at day 3 may be a useful additional criterion for embryo transfer %+ Centre Hospitalier Universitaire d'Angers (CHU Angers) %+ Laboratoire de Biologie Neurovasculaire Intégrée [Angers] (CNRS UMR6214 - INSERM U771) %A Le Cruguel, Sebastien %A Ferré-L’hotellier, Véronique %A Moriniere, C. %A Lemerle, S. %A Reynier, Pascal %A Descamps, Philippe %A May-Panloup, Pascale %< avec comité de lecture %@ 1058-0468 %J Journal of Assisted Reproduction and Genetics %I Springer Verlag %V 30 %N 5 %P 683 - 90 %8 2013 %D 2013 %R 10.1007/s10815-013-9983-3 %Z Life Sciences [q-bio]Journal articles %X
PURPOSE: The reduction of the number of embryos transferred while maintaining a satisfactory rate of pregnancy (PR) with in vitro fertilization calls for a refined technique of embryonic selection. This prospective study investigates the significance of early embryonic compaction at day 3 as a marker of the chances of implantation. METHODS: We examined 317 transfers and their outcome involving 509 embryos including 91 compacted embryos. RESULTS: Early compaction seems linked with the ovarian response to stimulation and embryonic quality. The PR is significantly increased when the embryonic cohort contains at least one compacted embryo (44% versus 29.5%, p = 0.01), and when at least one compacted embryo is transferred (44% versus 31%, p < 0.05). The analysis of our single embryo transfers shows that the implantation rates are significantly better for compacted embryos (50% versus 30%, p < 0.05) (OR 2.98; CI 1.02-5.28). CONCLUSION: Thus, early compaction, sometimes observed at day 3, may serve as a useful additional criterion for selecting the embryos transferred.
%G English %L hal-03403962 %U https://hal.univ-angers.fr/hal-03403962 %~ INSERM %~ CNRS %~ UNIV-ANGERS %~ UNAM