The effect of introducing IGRA to screen French healthcare workers for tuberculosis and potential conclusions for the work organisation - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Journal of Occupational Medicine and Toxicology Année : 2013

The effect of introducing IGRA to screen French healthcare workers for tuberculosis and potential conclusions for the work organisation

, , , , , , , , (1) ,
1
Adrien Moucaut
  • Fonction : Auteur
Albert Nienhaus
  • Fonction : Auteur
Benedicte Courtois
  • Fonction : Auteur
Virginie Nael
  • Fonction : Auteur
Claire Longuenesse
  • Fonction : Auteur
Bruno Ripault
  • Fonction : Auteur
Pierre Rucay
  • Fonction : Auteur
  • PersonId : 1114131
Stéphanie Moisan-Templereau
  • Fonction : Auteur
  • PersonId : 1114253
Dominique Tripodi
  • Fonction : Auteur
  • PersonId : 918368

Résumé

INTRODUCTION: In France, pre-employment screening for tuberculosis (TB) is performed for healthcare workers (HCW). Screening is repeated when exposure to TB patients or infectious material occurs. The results of these TB screenings were analysed in a retrospective analysis.

METHOD: Tuberculin skin tests (TST) and interferon-gamma release assays (QuantiFERON® Gold In-Tube - QFT) were used to perform the TB screenings. The screening results of 637 HCWs on whom QFT was performed were taken from the records of the University Hospital of Nantes.

RESULTS: In three (0.5%) HCW, the QFT was indeterminate. In 22.2%, the QFT was positive. A second QFT was performed in 118 HCWs. The reversion rate was 42% (5 out of 17). The conversion rate was 6% (6 out of 98). A TST was performed on 466 (73.5%) of the HCWs. Results for TST > 10 mm were 77.4%. In those with a TST < 10 mm, QFT was positive in 14% and in those with a TST ≥ 10 mm, QFT was positive in 26.7%. Depending on the definition for conversion in the QFT, the annual attack rate was 4.1% or 7.3%. X-ray and pneumology consultation was based on positive QFT rather than TST alone (52 out of 56). No active TB was detected.

CONCLUSION: The TST overestimated the prevalence of LTBI in this cohort. The decision about X-ray and consultation regarding preventive treatment should be based on the QFT rather than the TST results. The high reversion rate should be taken into consideration when consulting with HCWs regarding preventive treatment. The high conversion rate seems to indicate that preventive measures such as wearing masks should be improved.

Fichier principal
Vignette du fichier
moucaut-2013-jomt-12.pdf (231.13 Ko) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-03391065 , version 1 (21-10-2021)

Licence

Paternité - CC BY 4.0

Identifiants

Citer

Adrien Moucaut, Albert Nienhaus, Benedicte Courtois, Virginie Nael, Claire Longuenesse, et al.. The effect of introducing IGRA to screen French healthcare workers for tuberculosis and potential conclusions for the work organisation. Journal of Occupational Medicine and Toxicology, 2013, 8, pp.12. ⟨10.1186/1745-6673-8-12⟩. ⟨hal-03391065⟩
7 Consultations
16 Téléchargements

Altmetric

Partager

Gmail Facebook Twitter LinkedIn More