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Article Dans Une Revue Journal of Neuroimmunology Année : 2014

Treg depletion followed by intracerebral CpG-ODN injection induce brain tumor rejection

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Ulrich Jarry
  • Fonction : Auteur
Sabrina Donnou
  • Fonction : Auteur
Marie Vincent
  • Fonction : Auteur
Laurent Pineau
  • Fonction : Auteur
Isabelle Frémaux
  • Fonction : Auteur

Résumé

Using brain lymphoma model, we demonstrate that immunotherapy combining Treg depletion (using anti-CD25 mAb PC61) followed by intracranial CpG-ODN administration induced tumor rejection in all treated mice and led to the establishment of a memory antitumor immune response in 60% of them. This protective effect was associated with a recruitment of NK cells and, to a lesser extent, of dendritic cells, B cells and T lymphocytes. NK cell depletion abolished the protective effect of the treatment, confirming a major role of NK cells in brain tumor elimination. Each treatment used alone failed to protect brain tumor bearing mice, revealing the therapeutic benefit of combining Treg depletion and local CpG-ODN injection.

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hal-03389734 , version 1 (21-10-2021)

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Ulrich Jarry, Sabrina Donnou, Marie Vincent, Pascale Jeannin, Laurent Pineau, et al.. Treg depletion followed by intracerebral CpG-ODN injection induce brain tumor rejection. Journal of Neuroimmunology, 2014, 267 (1–2), pp.35 - 42. ⟨10.1016/j.jneuroim.2013.12.005⟩. ⟨hal-03389734⟩
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