Vitamin D concentration and lateral cerebral ventricle volume in older adults - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Molecular Nutrition and Food Research Année : 2013

Vitamin D concentration and lateral cerebral ventricle volume in older adults

(1) , , , , , (1)
1
Manuel Montero-Odasso
  • Fonction : Auteur
V. Hachinski
  • Fonction : Auteur
S. Seshadri
  • Fonction : Auteur
R. Bartha
  • Fonction : Auteur

Résumé

Scope Vitamin D deficiency is associated with an enlargement of the lateral cerebral ventricles in rodents. The effect of low serum 25-hydroxyvitamin D (25OHD) on lateral cerebral ventricle volume has not been studied yet in humans. The purpose of this cross-sectional study was to determine whether vitamin D deficiency was associated with greater lateral cerebral ventricle volume in older adults. Methods and results Ninety-two Caucasian community-dwellers with no clinical hydrocephalus (mean, 72.2 +/- 6.2 years; 46.7% female) were divided into two groups according to serum 25OHD concentration (deficiency <= 50 nmol/L; normal > 50 nmol/L). Cerebral ventricular volume was quantified using semi-automated software from three-dimensional T1-weighted MRI. Age, gender, body mass index, blood pressure, education level, Mini-Mental State Examination, white matter lesions, and serum calcium concentrations were used as covariates. There was an inverse linear association between 25OHD concentration and ventricular volume (p = 0.049). Compared to individuals with normal 25OHD, those with 25OHD deficiency (n = 33) had 28% larger lateral ventricles (46.9 +/- 26.8 mL versus 36.6 +/- 16.4 mL, p = 0.026). Vitamin D deficiency was associated with an increase in ventricular volume (adjusted beta = 16.55, p = 0.023). The ventricular enlargement involved ventricle bodies (p = 0.025) but not temporal horns (p = 0.112). Conclusion Serum 25OHD deficiency was associated with larger lateral cerebral ventricles. These findings provide a scientific base for vitamin D replacement trials.

Dates et versions

hal-03355555 , version 1 (27-09-2021)

Identifiants

Citer

Cédric Annweiler, Manuel Montero-Odasso, V. Hachinski, S. Seshadri, R. Bartha, et al.. Vitamin D concentration and lateral cerebral ventricle volume in older adults. Molecular Nutrition and Food Research, 2013, 57 (2), pp.267-276. ⟨10.1002/mnfr.201200418⟩. ⟨hal-03355555⟩
6 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook Twitter LinkedIn More