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Article Dans Une Revue Age and Ageing Année : 2012

Sarcopenia and cognitive impairment in elderly women: results from the EPIDOS cohort

Gabor Abellan van Kan
  • Fonction : Auteur
M. Cesari
  • Fonction : Auteur
Sophie Gillette-Guyonnet
  • Fonction : Auteur
Charlotte Dupuy
  • Fonction : Auteur
F. Nourhashemi
  • Fonction : Auteur
Anne-Marie Schott
  • Fonction : Auteur
Olivier Beauchet
  • Fonction : Auteur
  • PersonId : 918859
B. Vellas
  • Fonction : Auteur
Yves Rolland


BACKGROUND: common pathophysiological pathways are shared between age-related body composition changes and cognitive impairment.

OBJECTIVE: evaluate whether current operative sarcopenia definitions are associated with cognition in community-dwelling older women.

DESIGN: cross-sectional analyses.

SUBJECTS: a total of 3,025 women aged 75 years and older.

MEASUREMENTS: body composition (assessed by dual energy X-ray absorptiometry) and cognition (measured by short portable mental status questionnaire) were obtained in all participants. Multivariate logistic regression models assessed the association of six operative definitions of sarcopenia with cognitive impairment. Gait speed (GS, measured over a 6-meter track at usual pace) and handgrip strength (HG, measured by a hand-held dynamometer) were considered additional factors of interest.

RESULTS: a total of 492 (16.3%) women were cognitively impaired. The prevalence of sarcopenia ranged from 3.3 to 18.8%. No sarcopenia definition was associated with cognitive impairment after controlling for potential confounders. To proof consistency, the analyses were performed using GS and HG, two well-established predictors of cognitive impairment. Low GS [odds ratio (OR) 2.42, 95% confidence interval (CI) 1.72-3.40] and low HG (OR: 1.81, 95% CI: 1.33-2.46) were associated with cognitive impairment.

CONCLUSION: no significant association was evidenced between different operative sarcopenia definitions and cognitive impairment. The study suggests that the association between physical performance and cognitive impairment in not mediated by sarcopenia.

Dates et versions

hal-03355517 , version 1 (27-09-2021)



Gabor Abellan van Kan, M. Cesari, Sophie Gillette-Guyonnet, Charlotte Dupuy, F. Nourhashemi, et al.. Sarcopenia and cognitive impairment in elderly women: results from the EPIDOS cohort. Age and Ageing, 2012, 42 (2), pp.196-202. ⟨10.1093/ageing/afs173⟩. ⟨hal-03355517⟩
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