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Chapitre D'ouvrage Année : 2008

Experimental models of Acinetobacter infections

(1) ,
Michel Wolff
  • Fonction : Auteur


The use of animals as models for microbiological infections is a fundamental part of infectious disease research. The intent for the use of animals as models of disease is to establish an infection that mimics that seen in humans (Druilhe et al., 2002). The goal is to seek how the infection develops, and by what the infection can be thwarted. Hence, animal models can be proposed to study the virulence and pathogenicity of a microorganism or to screen candidate antibiotics for their performance in eliminating the infection. Because Acinetobacter frequently develops resistance to antibiotics, experimental models of infection are useful in pharmacokinetic assays and/or for the study of various antibiotic regimens. Study on virulence is still in an elementary stage. The use of animal models must be approved by the Ethical Committee for animal experiments.
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hal-03333602 , version 1 (07-09-2021)


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Marie-Laure Joly-Guillou, Michel Wolff. Experimental models of Acinetobacter infections. Acinetobacter Biology Infections and Pathogenesis, Springer; https://link.springer.com/chapter/10.1007%2F978-0-387-77944-7_10, pp.167-174, 2008, ⟨10.1007/978-0-387-77944-7_10⟩. ⟨hal-03333602⟩


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