Microparticles harboring sonic hedgehog: Role in angiogenesis regulation - Université d'Angers Accéder directement au contenu
Article Dans Une Revue Cell adhesion and migration Année : 2009

Microparticles harboring sonic hedgehog: Role in angiogenesis regulation

Résumé

Sonic Hedgehog (Shh) is a morphogen involved in embryonic development of nervous system. Also, it has been shown that recombinant Shh can modulate angiogenesis under ischemic conditions. However, angiogenic effects of endogenous Shh have not been completely elucidated. Using small membrane-derived vesicles expressing Shh (MPsShh+), we have shown that, although MPsShh+ decrease endothelial cell proliferation and migration, they are able to favour angiogenesis through the increase of both endothelial cell adhesion and expression of pro-angiogenenic factors. Activation of proteins implicated in cell adhesion, such as Rho A, as well as upregulation of pro-angiogenic factors were sensitive to inhibition of Shh pathway. Although whole composition of MPsShh+ needs to be characterized to understand potential effects of MPsShh+, these results highlight a new role of MPsShh+ in vascular pathophysiology and may have significant implication for therapy in pathologies associated with altered angiogenesis in order to re-address angiogenic switch.

Dates et versions

hal-03275809 , version 1 (01-07-2021)

Identifiants

Citer

Raffaella Soleti, Maria Carmen Martinez. Microparticles harboring sonic hedgehog: Role in angiogenesis regulation. Cell adhesion and migration, 2009, 3 (3), pp.293 - 295. ⟨10.4161/cam.3.3.9121⟩. ⟨hal-03275809⟩

Collections

CNRS UNIV-ANGERS
8 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More