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Article Dans Une Revue European Journal of Cancer Année : 2020

European interdisciplinary guideline on invasive squamous cell carcinoma of the skin: Part 1. epidemiology, diagnostics and prevention

1 NKUA - National and Kapodistrian University of Athens
2 Eberhard Karls Universität Tübingen = Eberhard Karls University of Tuebingen
3 HIPI (UMR_S_976 / U976) - Immunologie humaine, physiopathologie & immunothérapie
4 North & East Hertfordshire NHS Trust [Northwood, UK]
5 OUH - Odense University Hospital
6 CRCINA - Centre de Recherche en Cancérologie et Immunologie Nantes-Angers
7 CIC Nantes - Centre d’Investigation Clinique de Nantes
8 UNIVAQ - University of L'Aquila [Italy]
9 UMPCD - University of Medicine and Pharmacy “Carol Davila” Bucharest
10 QMUL - Queen Mary University of London
11 CAU - Christian-Albrechts-Universität zu Kiel = Christian-Albrechts University of Kiel = Université Christian-Albrechts de Kiel
12 Medizinische Universität Wien = Medical University of Vienna
13 2MA - Military Medical Academy [Belgrade, Serbia]
14 Frankfurt University Hospital
15 MUMC - Maastricht University Medical Centre
16 University of Barcelona
17 IDIBAPS - Institut d'Investigacions Biomèdiques August Pi i Sunyer
18 CIBER de Enfermedades Raras (CIBERER)
19 ISC - Instituto de Salud Carlos III [Madrid]
20 ULB - Université libre de Bruxelles
21 Hôpital Erasme [Bruxelles]
22 University of Oxford
23 HUVM - Hospital Universitario Virgen Macarena [Sevilla, Spain]
24 University - Hospital of Modena and Reggio Emilia [Modena, Italy]
25 Unicatt - Università cattolica del Sacro Cuore = Catholic University of the Sacred Heart [Roma]
26 Fondazione Policlinico Universitario Agostino Gemelli IRCCS
27 NEUROMED I.R.C.C.S. - Istituto Neurologico Mediterraneo
28 BECCOH - Biomarqueurs et essais cliniques en Cancérologie et Onco-Hématologie
29 Hôpital Ambroise Paré [AP-HP]
30 University Veterinary Hospital [Coimbra, Portugal]
31 Università degli studi di Trieste = University of Trieste
32 Princess Máxima Center for Pediatric Oncology
33 APHM - Assistance Publique - Hôpitaux de Marseille
34 AMU - Aix Marseille Université
Lars Bastholt
Maria Concetta Fargnoli

Résumé

Invasive cutaneous squamous cell carcinoma (cSCC) is one of the most common cancers in the white populations, accounting for 20% of all cutaneous malignancies. Factors implicated in cSCC etiopathogenesis include ultraviolet radiation exposure and chronic photoaging, age, male sex, immunosuppression, smoking and genetic factors. A collaboration of multidisciplinary experts from the European Dermatology Forum (EDF), the European Association of Dermato-Oncology (EADO) and the European Organisation of Research and Treatment of Cancer (EORTC) was formed to update recommendations on cSCC classification, diagnosis, risk stratification, staging and prevention, based on current literature, staging systems and expert consensus. Common cSCCs are typically indolent tumors, and most have a good prognosis with 5-year cure rates of greater than 90%, and a low rate of metastases (<4%). Further risk stratification into low-risk or high-risk common primary cSCC is recommended based on proposed high-risk factors. Advanced cSCC is classified as locally advanced (lacSCC), and metastatic (mcSCC) including locoregional metastatic or distant metastatic cSCC. Current systems used for staging include the American Joint Committee on Cancer (AJCC) 8th edition, the Union for International Cancer Control (UICC) 8th edition, and Brigham and Women's Hospital (BWH) system. Physical examination for all cSCCs should include total body skin examination and clinical palpation of lymph nodes, especially of the draining basins. Radiologic imaging such as ultrasound of the regional lymph nodes, magnetic resonance imaging (MRI), computed tomography (CT), positron emission tomography–computed tomography (PET-CT) scans are recommended for staging of high-risk cSCC. Sentinel lymph node biopsy is currently not recommended. Nicotinamide, oral retinoids, and topical 5-FU have been used for the chemoprevention of subsequent cSCCs in high-risk patients but are not routinely recommended. Education about sun protection measures including reducing sun exposure, use of protective clothing, regular use of sunscreens and avoidance of artificial tanning, is recommended.

Dates et versions

hal-03228150 , version 1 (17-05-2021)

Identifiants

Citer

Alexander John Stratigos, Claus Garbe, Clio Dessinioti, Célèste Lebbe, Véronique Bataille, et al.. European interdisciplinary guideline on invasive squamous cell carcinoma of the skin: Part 1. epidemiology, diagnostics and prevention. European Journal of Cancer, 2020, 128, pp.60-82. ⟨10.1016/j.ejca.2020.01.007⟩. ⟨hal-03228150⟩
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