The potential of combinations of drug-loaded nanoparticle systems and adult stem cells for glioma therapy - Université d'Angers Accéder directement au contenu
Article Dans Une Revue Biomaterials Année : 2011

The potential of combinations of drug-loaded nanoparticle systems and adult stem cells for glioma therapy

M. Roger
  • Fonction : Auteur
  • PersonId : 1368392
  • IdRef : 069831149
Anne Clavreul
Philippe Menei
  • Fonction : Auteur
  • PersonId : 910996
  • IdRef : 076585468

Résumé

The prognosis of patients with malignant glioma remains extremely poor, despite surgery and improvements in radio- and chemo-therapies. Nanotechnologies hold great promise in glioma therapy as they protect the therapeutic agent and allow its sustained release. However, new paradigms permitting tumor-specific targeting and extensive intratumoral distribution must be developed to efficiently deliver nanoparticles. Modifications and functionalizations of nanoparticles have been developed to specifically track tumor cells. However, these nanoparticles have yielded few clinical results due to intra-patient heterogeneity and inter-patient variability. Stem cells with a specific tropism for brain tumors could be used as delivery vehicles for nanoparticles. Indeed, these cells have a natural tendency to migrate and distribute within the tumor mass and they can also incorporate nanoparticles. Stem cell therapy combined with nanotechnology could be a promising tool to efficiently deliver drugs to brain tumors.

Fichier non déposé

Dates et versions

hal-03165474 , version 1 (10-03-2021)

Identifiants

  • HAL Id : hal-03165474 , version 1
  • OKINA : ua3673

Citer

M. Roger, Anne Clavreul, Marie-Claire Venier-Julienne, Catherine Passirani-Malleret, Claudia Montero-Menei, et al.. The potential of combinations of drug-loaded nanoparticle systems and adult stem cells for glioma therapy. Biomaterials, 2011, 32 (8), pp.1560-1573. ⟨hal-03165474⟩
24 Consultations
0 Téléchargements

Partager

Gmail Facebook X LinkedIn More