Signaling Pathways Governing the Caspofungin Paradoxical Effect in Aspergillus fumigatus - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue mBio Année : 2020

Signaling Pathways Governing the Caspofungin Paradoxical Effect in Aspergillus fumigatus

(1) , ,
1
Florent Morio
Dominique Sanglard
  • Fonction : Auteur

Résumé

Aspergillus fumigatus is responsible for a wide range of diseases affecting several million people worldwide. Currently, a few families of antifungals are available to fight aspergillosis, and we are facing a worrisome increase in resistance to azoles, the drugs used for both first-line treatment and prophylaxis of invasive aspergillosis. In this context, some of the latest antifungals, i.e., echinocandins, have gained attention. Even though acquired resistance to echinocandins is yet uncommon in A. fumigatus clinical isolates, some strains exhibit another characteristic that relies on their capacity to grow at suprainhibitory echinocandin concentrations in vitro .

Dates et versions

hal-02942844 , version 1 (18-09-2020)

Identifiants

Citer

Nicolas Papon, Florent Morio, Dominique Sanglard. Signaling Pathways Governing the Caspofungin Paradoxical Effect in Aspergillus fumigatus. mBio, 2020, 11 (4), pp.1816-20. ⟨10.1128/mBio.01816-20⟩. ⟨hal-02942844⟩

Collections

UNIV-ANGERS
31 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook Twitter LinkedIn More