Association of maternal nutrition with transient neonatal hyperinsulinism - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue PLoS ONE Année : 2018

Association of maternal nutrition with transient neonatal hyperinsulinism

, (1) , (2) , , , , (3, 4) , (5, 6) , (7) , (7)


OBJECTIVE: The objective was to determine whether maternal nutritional factors are associated with transient neonatal hyperinsulinism (HI).

DESIGN AND SETTING: Case control study in 4 French tertiary Obstetrics and Neonatology Departments between 2008 and 2015.

METHODS: Sixty-seven mothers of neonates diagnosed with transient hyperinsulinism and 113 mothers of controls were included. The screening for hyperinsulinemic hypoglycemia in neonates was performed because of clinical symptoms suggestive of hypoglycemia or in the presence of conventional risk factors (small-for-gestational-age, prematurity, anoxo-ischemia, hypothermia, macrosomia, gestational diabetes). Hyperinsulinemic hypoglycemia was confirmed in the HI neonates and ruled out in the controls. This allowed for comparing maternal nutrition in cases and controls in a context of similar risk factors. One to 2 mothers of control neonates were included per case, and a food frequency questionnaire was addressed to the mothers between day 5 and day 10 after the birth of their newborn.

RESULTS: Crude odds ratio showed that maternal weight gain, abnormal fetal rate, C-section, gender, consumption of fresh cooked vegetables, fresh fruits and fruit juices, low fat diary products, light fat products, and daily bread were significantly associated with hyperinsulinism. Maternal body mass index, hypertension, gestational diabetes, birth weight percentile, gestational age and 5-minute Apgar score were not related to HI. In a multiple backward logistic regression model, consumption of fresh cooked vegetable ≥1/day (OR = 0.33 [0.14-0.77]) and light-fat products ≥1/week (OR = 0.24 [0.08-0.71]) was protective against hyperinsulinism, whereas gestational weight gain >20 kg (OR = 9.5 [2.0-45.5]) and between 15-20 kg (OR = 4.0 [1.2-14.0]), abnormal fetal heart rate (OR = 4.4 [1.6-12.0]), and C-section (OR = 3.4 [1.3-8.9]) were risk factors.

CONCLUSIONS: A diet rich in fresh cooked vegetable and reduced in fat, together with the avoidance of a high gestational weight gain may be protective against transient neonatal hyperinsulinism.

Fichier principal
Vignette du fichier
2018_Louvigne_Plos One_1.pdf (2.39 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-02616858 , version 1 (26-05-2020)


Paternité - CC BY 4.0



Mathilde Louvigne, Stéphanie Rouleau, Emmanuelle Caldagues, Isabelle Souto, Yanis Montcho, et al.. Association of maternal nutrition with transient neonatal hyperinsulinism. PLoS ONE, 2018, 13 (5), pp.e0195383. ⟨10.1371/journal.pone.0195383⟩. ⟨hal-02616858⟩
32 Consultations
41 Téléchargements



Gmail Facebook Twitter LinkedIn More