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Article Dans Une Revue Drug Discovery Today Année : 2017

Models for drug absorption from the small intestine: where are we and where are we going?

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Pierre-André Billat
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Emilie Roger
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Sébastien Faure
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Frédéric Lagarce
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Résumé

The small intestine is a complex organ with movements, flora, mucus and flows. Despite this, the most widely used absorption models consider the organ a cylindrical monoepithelial tube. This review presents the recent evolution of models to take into consideration the complex nature of gut physiology. The most commonly encountered issues are ethical (in vivo models) and differences in drug transport as a result of a modified expression of drug transporters or metabolic enzymes compared with human (in vitro and in vivo models). Finally, this review discusses the way forward to reach an ideal equilibrium between reproducibility, predictability and efficiency for predicting permeability. The features of an ideal model are listed as a guideline for future development.

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Dates et versions

hal-02615955 , version 1 (07-09-2021)

Licence

Paternité - CC BY 4.0

Identifiants

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Pierre-André Billat, Emilie Roger, Sébastien Faure, Frédéric Lagarce. Models for drug absorption from the small intestine: where are we and where are we going?. Drug Discovery Today, 2017, 22 (5), pp.761-775. ⟨10.1016/j.drudis.2017.01.007⟩. ⟨hal-02615955⟩
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