Inhibitory effects of Blackstonia grandiflora extracts on the formation of advanced glycation end products (AGEs) - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Der pharma chemica Année : 2016

Inhibitory effects of Blackstonia grandiflora extracts on the formation of advanced glycation end products (AGEs)

, , , (1) , (2)
1
2

Résumé

Glycation, the nonenzymatic reaction of reducing sugars with amino groups, is increased in hyperglycemic physiological environments, leading to an acceleration of the formation of advanced glycation end products (AGEs). The AGEs are associated with many pathogenic disorders such as Alzheimer’s disease, pathogenesis of diabetes, and atherosclerosis. They are also responsible for aging and tissue damage. In this study, the antiglycation activity of the extracts Blackstonia grandiflora (Viv.) was evaluated in the bovine serum albumin (BSA)/ribose system and the potency of these extracts was compared with the standard antiglycation agent aminoguanidine. The results showed that EtOAc extract had a significant inhibitory effect on the formation of advanced glycation end products (AGEs).
Fichier non déposé

Dates et versions

hal-02521257 , version 1 (27-03-2020)

Identifiants

  • HAL Id : hal-02521257 , version 1
  • OKINA : ua15412

Citer

Fatima Zohra Belfadel, Kamel Medjroubi, Salah Akkal, Séverine Derbré, Elisabeth Seguin. Inhibitory effects of Blackstonia grandiflora extracts on the formation of advanced glycation end products (AGEs). Der pharma chemica, 2016, 15 (8), pp.146-149. ⟨hal-02521257⟩
91 Consultations
0 Téléchargements

Partager

Gmail Facebook Twitter LinkedIn More