Potential of Chemically Synthesized Oligosaccharides To Define the Carbohydrate Moieties of the Fungal Cell Wall Responsible for the Human Immune Response, Using Aspergillus fumigatus Galactomannan as a Model - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue MSphere Année : 2020

Potential of Chemically Synthesized Oligosaccharides To Define the Carbohydrate Moieties of the Fungal Cell Wall Responsible for the Human Immune Response, Using Aspergillus fumigatus Galactomannan as a Model

(1) , (2) , (2) , (2) , (3) , (1) , (1) , (2)
1
2
3

Résumé

Methodologies to identify epitopes or ligands of the fungal cell wall polysaccharides influencing the immune response of human pathogens have to date been imperfect. Using the galactomannan (GM) of Aspergillus fumigatus as a model, we have shown that synthetic oligosaccharides of distinct structures representing key fragments of cell wall polysaccharides are the most precise tools to study the serological and immunomodulatory properties of a fungal polysaccharide.
Fichier principal
Vignette du fichier
mSphere-2020-Wong-e00688-19.full.pdf (1.07 Mo) Télécharger le fichier
Origine : Publication financée par une institution
Loading...

Dates et versions

hal-02483291 , version 1 (19-02-2020)

Licence

Paternité - CC BY 4.0

Identifiants

Citer

Sarah Sze Wah Wong, Vadim Krylov, Dmitry Argunov, Alexander Karelin, Jean-Phillipe Bouchara, et al.. Potential of Chemically Synthesized Oligosaccharides To Define the Carbohydrate Moieties of the Fungal Cell Wall Responsible for the Human Immune Response, Using Aspergillus fumigatus Galactomannan as a Model. MSphere, 2020, 5 (1), pp.e00688-19. ⟨10.1128/mSphere.00688-19⟩. ⟨hal-02483291⟩
93 Consultations
74 Téléchargements

Altmetric

Partager

Gmail Facebook Twitter LinkedIn More