Posttranscriptional control of mitochondrial biogenesis: Spatio‐temporal regulation of the protein import process
Résumé
This review focuses on the posttranscriptional processes which govern mitochondrial biogenesis, with a special emphasis on the asymmetric localization–translation of nuclear‐encoded mRNAs as an important regulatory step of the protein import process. We review how spatio‐temporal mRNA regulons help to elicit timely, versatile, and coordinated intracellular processes to assemble mitochondrial structures. Our current knowledge on the mitochondrial import of respiratory chain assembly factors and the role of the ribonucleic acid (RNA) binding protein Puf3 are presented. A connection with the target of rapamycine signalling pathway may explain how respiratory chain assembly senses environmental conditions via the protein import machinery.
Mots clés
RNA regulon Mitochondria TOR pathway Post-genomics RNA
ribonucleic acid ADP
adenosine diphosphate ATP
adenosine triphosphate rRNA
ribosomal RNA TOR
target of rapamycine OXPHOS
oxidative phosphorylation MLR
mitochondrially localized RNA MTS
mitochondrial targeting sequence
ribonucleic acid
ADP
adenosine diphosphate
ATP
adenosine triphosphate
rRNA
ribosomal RNA
TOR
target of rapamycine
OXPHOS
oxidative phosphorylation
MLR
mitochondrially localized RNA
MTS
Domaines
Sciences du Vivant [q-bio]| Origine | Fichiers produits par l'(les) auteur(s) |
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