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Dernières publications
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Medhi Hassani, Dylan Moutachi, Mégane Lemaitre, Alexis Boulinguiez, Denis Furling, et al.. Beneficial effects of resistance training on both mild and severe mouse dystrophic muscle function as a preclinical option for Duchenne muscular dystrophy. PLoS ONE, 2024, 19, ⟨10.1371/journal.pone.0295700⟩. ⟨hal-04501283⟩
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Florent Porquet, Lin Weidong, Kévin Jehasse, Hélène Gazon, Maria Kondili, et al.. Specific DMPK-promoter targeting by CRISPRi reverses myotonic dystrophy type 1-associated defects in patient muscle cells. Molecular Therapy - Nucleic Acids, 2023, 32, pp.857 - 871. ⟨10.1016/j.omtn.2023.05.007⟩. ⟨hal-04287597⟩
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Caroline Le Guiner, T Larcher, A Lafoux, G Toumaniantz, S Webb, et al.. Characterization of the muscular and cardiac diseases of the DMSXL mouse model, a transgenic mouse model for Myotonic Dystrophy type 1. American Society of Gene & Cell Therapy, May 2023, LOS ANGELES, United States. ⟨hal-04096181⟩
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Dylan Moutachi, Mégane Lemaitre, Clément Delacroix, Onnik Agbulut, Denis Furling, et al.. Valproic acid reduces muscle susceptibility to contraction‐induced functional loss but increases weakness in two murine models of Duchenne muscular dystrophy. Clinical and Experimental Pharmacology and Physiology, In press, ⟨10.1111/1440-1681.13804⟩. ⟨hal-04146953⟩
Chiffres clés
132
Publications avec texte intégral
Open Access
52 %
Mots clés
CRISPRi
Maximal force
Heart
Mice
Desmin
Gene editing
Animals
Male
Myotonic Dystrophy Type 1
DMPK
Glutamate
Mouse model
Humans
Glucocorticoid-receptor
GSK3
Motoneuron
Oligodendrocytes
Trinucleotide Repeat Expansion
Myotonic dystrophy
PacBio
Myostatin
Transcriptomics
Dystrophin
Antisense oligonucleotides
Dynamin 2
CMS
Transgenic mouse
RNA biology
PCR
Central nervous system
Myelin
Aging
Myotonic Dystrophy
Astrocytes
Centronuclear myopathy
Trinucleotide repeat expansion
Oligodendrocyte
Heart failure
Brain
Astrocyte
Skeletal muscle
Antisense oligonucleotide
Alternative splicing
Brain dysfunction
MBNL
Long read sequencing
GABA
Exercise
Duchenne muscular dystrophy
ARN
Genotype phenotype correlation
Cell culture model
ACETYLCHOLINESTERASE
DMSXL mice
Lc3
BIOLOGIE MOLECULAIRE
Gene therapy
Diaphragm
Hypoxia
Mouse models
Myotonic Dystrophy type 1
Acute coronary syndrome
CTG repeat contractions
Knockout
Myotonic dystrophy type 1
KNOCKOUT MICE
Glucocorticoids
Cytoskeleton
AAV
Neuron
Thérapie génique
Autophagy
Gene Therapy
Muscular dystrophy
Dystrophie Myotonique
Intermediate filament
Muscle
Glial cells
Dystrophie myotonique
Exercice
Expression
CTG repeat instability
In vivo
CONGENITAL MYATHENIC SYNDROME
Acetylcholinesterase deficiency
Transgenic mouse model
RNA splicing
Dilated cardiomyopathy
CRISPR/Cas9
Acetylcholinesterase knockout mouse
Cell penetrating peptide
Fibrosis
RNA interference
CTG repeats
Myotonic dystrophy mouse models
Cardiac muscle
Therapy
Cell model
DM1
Quantitative microdialysis