Long-term outcome of diarrhea-associated hemolytic uremic syndrome is poorly related to markers of kidney injury at 1-year follow-up in a population-based cohort - Bordeaux Population Health Accéder directement au contenu
Article Dans Une Revue Pediatric Nephrology Année : 2019

Long-term outcome of diarrhea-associated hemolytic uremic syndrome is poorly related to markers of kidney injury at 1-year follow-up in a population-based cohort

C. Monet-Didailler
  • Fonction : Auteur
A. Godron-Dubrasquet
  • Fonction : Auteur
I. Madden
  • Fonction : Auteur
Y. Delmas
  • Fonction : Auteur
B. Llanas
  • Fonction : Auteur

Résumé

BACKGROUND: Hemolytic uremic syndrome due to Shiga toxin-producing E. coli (STEC-HUS) is the main cause of acute kidney injury in young children. Most fully recover kidney function; however, some develop long-term sequelae. We aimed to determine whether kidney injury 1 year after HUS onset is associated with long-term kidney outcome in pediatric STEC-HUS. METHODS: A retrospective population-based study of children < 15 years with STEC-HUS between 1992 and 2012 was performed. Mixed effects logistic regression was used to investigate associations between kidney injury at 1 year and long-term kidney outcome. RESULTS: Ninety-eight STEC-HUS cases were reported. Of 96 patients who survived acute phase, 84 were evaluated at 1-year follow-up of whom 42 (44% of survivors) showed >/= 1 signs of kidney injury. Data from 81 patients were collected after median follow-up of 8.7 (IQR 3.5-12.7) years. At last follow-up, 42 (44% of survivors) had >/= 1 signs of kidney injury including decreased estimated glomerular filtration rate (eGFR) < 90 mL/min/1.73 m(2) (n = 30), proteinuria (n = 17), or hypertension (n = 5). Among 42 patients with kidney injuries at 1-year follow-up, only 22 (52%) still had kidney disease at last follow-up. Conversely, of 33 patients without kidney injury at 1-year and available long-term outcome data, 11 (33%) had proteinuria or decreased GFR at last follow-up. There was no statistically significant association between kidney injury at 1 year and long-term kidney outcome. CONCLUSIONS: Since kidney sequelae may appear at variable time intervals after acute HUS, all patients need lifelong follow-up to detect early signs of chronic kidney disease and propose measures to slow progression.

Mots clés

Fichier non déposé

Dates et versions

hal-03162451 , version 1 (08-03-2021)

Identifiants

Citer

C. Monet-Didailler, A. Godron-Dubrasquet, I. Madden, Y. Delmas, B. Llanas, et al.. Long-term outcome of diarrhea-associated hemolytic uremic syndrome is poorly related to markers of kidney injury at 1-year follow-up in a population-based cohort. Pediatric Nephrology, 2019, 34 (4), pp.657-662. ⟨10.1007/s00467-018-4131-z⟩. ⟨hal-03162451⟩

Collections

U1219
11 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More