Sarcoma treatment in the era of molecular medicine - Sarcomes Osseux et Remodelage des Tissus Calcifiés
Article Dans Une Revue EMBO Molecular Medicine Année : 2020

Sarcoma treatment in the era of molecular medicine

1 University Hospital LMU Munich
2 KITZ - Hopp Children's Cancer Center Heidelberg [Heidelber, Germany]
3 Heidelberg University Hospital [Heidelberg]
4 UNAV - Universidad de Navarra [Pamplona]
5 IRCCS Istituto Ortopedico Rizzoli
6 DKFZ - German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg]
7 TUM - Technische Universität Munchen - Technical University Munich - Université Technique de Munich
8 St. Anna Children’s Cancer Research Institute CCRI [Vienna]
9 Charité - UniversitätsMedizin = Berlin University Medicine
10 ISCIII - Instituto de Salud Carlos III [Madrid]
11 King‘s College London
12 University Hospital Erlangen = Uniklinikum Erlangen
13 CIMA - Center for Applied Medical Research [Plamplona]
14 IBB - Institute of biostructures and bioimaging
15 University of Sheffield [Sheffield]
16 University of Heidelberg, Medical Faculty
17 Phy-Os - Sarcomes osseux et remodelage des tissus calcifiés - Phy-Os [Nantes - INSERM U1238]
18 UC - Universidade de Coimbra = University of Coimbra [Portugal]
19 Universidad de Oviedo = University of Oviedo
20 CIBERONC - Centro de Investigación Biomédica en Red de Cáncer
21 Universität Ulm - Ulm University [Ulm, Allemagne]
22 University of Groningen [Groningen]
23 Helsingin yliopisto = Helsingfors universitet = University of Helsinki
24 UKM - University Hospital Münster - Universitaetsklinikum Muenster [Germany]
25 IdiPaz - Hospital La Paz Institute for Health Research [Madrid, Spain]
26 Radboud University Medical Center [Nijmegen]
27 Duke University School of Medicine [Durham, NC, USA]
28 University Children’s Hospital Zurich
29 UNIBO - Alma Mater Studiorum Università di Bologna = University of Bologna
30 UNICANCER/ICO - Institut de Cancérologie de l'Ouest [Angers/Nantes]
Gemma Di Pompo
Agamemnon E Grigoriadis
  • Fonction : Auteur
  • PersonId : 1033101
Silvia Lemma
  • Fonction : Auteur
  • PersonId : 1119965
Francesca Perut

Résumé

Sarcomas are heterogeneous and clinically challenging soft tissue and bone cancers. Although constituting only 1% of all human malignancies, sarcomas represent the second most common type of solid tumors in children and adolescents and comprise an important group of secondary malignancies. More than 100 histological subtypes have been characterized to date, and many more are being discovered due to molecular profiling. Owing to their mostly aggressive biological behavior, relative rarity, and occurrence at virtually every anatomical site, many sarcoma subtypes are in particular difficult-to-treat categories. Current multimodal treatment concepts combine surgery, polychemotherapy (with/without local hyperthermia), irradiation, immunotherapy, and/or targeted therapeutics. Recent scientific advancements have enabled a more precise molecular characterization of sarcoma subtypes and revealed novel therapeutic targets and prognostic/predictive biomarkers. This review aims at providing a comprehensive overview of the latest advances in the molecular biology of sarcomas and their effects on clinical oncology; it is meant for a broad readership ranging from novices to experts in the field of sarcoma.
Fichier principal
Vignette du fichier
main.pdf (1.93 Mo) Télécharger le fichier
Origine Publication financée par une institution
licence

Dates et versions

hal-03004281 , version 1 (06-01-2025)

Licence

Identifiants

Citer

Thomas Gp Grünewald, Marta Alonso, Sofia Avnet, Ana Banito, Stefan Burdach, et al.. Sarcoma treatment in the era of molecular medicine. EMBO Molecular Medicine, 2020, 12 (11), pp.e11131. ⟨10.15252/emmm.201911131⟩. ⟨hal-03004281⟩
17 Consultations
0 Téléchargements

Altmetric

Partager

More