Article Dans Une Revue Clinical Infection in Practice Année : 2025

Determinants of third-generation oral cephalosporin prescribing by general practitioners: A regional survey in France

Résumé

Introduction: Oral third-generation cephalosporins (3GC) are a major source of antibiotic resistance, with 70 % of prescriptions issued by general practitioners (GPs). The main objective of this study was to identify the factors that lead GPs to prescribe oral 3GCs. The secondary objective was to identify the physician profiles most likely to prescribe them. Materials and Methods: This was an observational, descriptive, declarative study. A questionnaire was distributed to GPs in a french area (Pays de le Loire). Results: We included 74 responses from GPs. Several determinants were identified that positively influenced the prescription of oral 3GCs: situations of therapeutic failure (64.9 % of GPs), penicillin allergy (49.5 %), altered general condition (35.2 %), age over 65 (33.8 %). Physicians practising in semi-rural and rural areas seemed to be more inclined to prescribe 3GCs in cases of altered general condition (p < 0.027) or diagnostic doubt (p < 0.025). Conclusion: The results of this study can be used to tailor GP training to the context in which they provide care.

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hal-05284839 , version 1 (26-09-2025)

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Astrid Descolas, Jérôme Ramassamy, Thibaut Riom, Jérémy Lellouch, Matthieu Peurois. Determinants of third-generation oral cephalosporin prescribing by general practitioners: A regional survey in France. Clinical Infection in Practice, 2025, 28, ⟨10.1016/j.clinpr.2025.100514⟩. ⟨hal-05284839⟩
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