Orientia tsutsugamushi, agent of scrub typhus, displays a single metapopulation with maintenance of ancestral haplotypes throughout continental South East Asia - Biologie, Ecologie, Evolution, Environnement, Sciences de la Terre et de l'Eau Accéder directement au contenu
Article Dans Une Revue Infection, Genetics and Evolution Année : 2015

Orientia tsutsugamushi, agent of scrub typhus, displays a single metapopulation with maintenance of ancestral haplotypes throughout continental South East Asia

Résumé

Orientia tsutsugamushi is the causative agent of scrub typhus, a major cause of febrile illness in rural area of Asia-Pacific region. A multi-locus sequence typing (MLST) analysis was performed on strains isolated from human patients from 3 countries in Southeast Asia: Cambodia, Vietnam and Thailand. The phylogeny of the 56-kDa protein encoding gene was analyzed on the same strains and showed a structured topology with genetically distinct clusters. MLST analysis did not lead to the same conclusion. DNA polymorphism and phylogeny of individual gene loci indicated a significant level of recombination and genetic diversity whereas the ST distribution indicated the presence of isolated patches. No correlation was found with the geographic origin. This work suggests that weak divergence in core genome and ancestral haplotypes are maintained by permanent recombination in mites while the 56-kDa protein gene is diverging in higher speed due to selection by the mammalian immune system.
Fichier principal
Vignette du fichier
SEA_IGE2015.pdf (261.56 Ko) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte
licence : CC BY - Paternité

Dates et versions

hal-03048806 , version 1 (18-04-2023)

Licence

Paternité - Pas d'utilisation commerciale

Identifiants

Citer

Patimaporn Wongprompitak, Veasna Duong, Wichittra Anukool, Lay Sreyrath, Trinh Thi Xuan Mai, et al.. Orientia tsutsugamushi, agent of scrub typhus, displays a single metapopulation with maintenance of ancestral haplotypes throughout continental South East Asia. Infection, Genetics and Evolution, 2015, 31, pp.1-8. ⟨10.1016/j.meegid.2015.01.005⟩. ⟨hal-03048806⟩
35 Consultations
11 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More